FXN and Friedreich ataxia: Here, we chose to investigate the histone modifications of YG8JR FRDA mouse models in cerebellum, because this tissue plays a key role in FRDA pathology (Koeppen et al., 2007) and frataxin expression is markedly reduced in FRDA cerebellum compared to brain and brain stem tissues (Al-Mahdawi et al., 2006).