FXN and Friedreich ataxia: The analysis revealed increased acetylation of H3K9 in FXN promoter/exon1 region of the YG8JR mice compared to the Y47JR mice (Figure 5A), which was contradictory to the findings in previous YG8R and YG22R mouse models and human FRDA brain tissues (Herman et al., 2006; Al-Mahdawi et al., 2008).