TNF and Stroke: Among them, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), and IL-6 are increased after stroke, and this process may be explained by “cytokine storm” (Tao et al., 2015; Xia et al., 2018; Zhu et al., 2018; Vogelgesang et al., 2019).