It is known that multiple factors including the intraocular microenvironment affected the progression of AMD.The immune regulation of RPE cells in the intraocular microenvironment depends on the ability of RPE cells to express cell surface molecules and soluble inhibitors, such as transforming growth factor β (TGF- β), pigment epithelium-derived factor (PEDF), complement regulatory proteins (CD46, CD55, and CD59a), and interleukin (IL)-1 receptor antagonist [31, 32]. This evidence concerns the gene CD55 and age-related macular degeneration.