CDC73 and familial isolated hyperparathyroidism: A latest review of APA summarized the inactivating CDC73 mutations in various studies, finding 36.5% (23/63) cases carrying germline mutations, including two large deletions spanning exons 1–10 of the gene, most of them being found in familial cases (11 patients with FIHP and 4 with HPT-JT) and 7 in apparently sporadic PHPT (6).