Further up the regulatory chain of hyperglycemia-induced EndMT, dietary supplements resveratrol and eicosapentaenoic acid have been shown to prevent EndMT in retinal and glomerular ECs respectively, by inhibiting PKC, thereby preventing the induction TGF-β and ET-1 (12, 24, 82, 176, 177). This evidence concerns the gene PRRT2 and Hyperglycemia.