The serine protease inhibitor α2-antiplasmin similarly bypasses TGF-β and induces Smad2/3 activation via AGE-induced responses (112).The SET domain-containing protein 8 (SETD8) regulates EndMT in diabetic neuropathy by directly regulating SNAI1; upregulation of SETD8 suppressed SNAI1, and prevented EndMT (86). This evidence concerns the gene KMT5A and diabetic neuropathy.