To assess whether changes in bone forming genes at CKD onset occur concurrently with changes in osteoclast markers, we measured gene expression of Acp5 (Tartrate-resistant acid phosphatase), Mmp9 (Matrix metallopeptidase 9), and Tnfrsf11a (Rank) by qPCR. This evidence concerns the gene TNFRSF11A and chronic kidney disease.