This analysis detected a downregulation of multiple osteoblast and osteocyte mRNAs except for bone Fgf23 that increased in CKD, or remained stable or were moderately induced, such as Mmp13 and Spp1. The pre-osteoblast gene sets tested in CKD suggested a step-wise decrease in progenitor alterations. The gene discussed is FGF23; the disease is chronic kidney disease.