Fecal calprotectin shows high sensitivity and a high negative predictive value for intestinal inflammation and is used to discriminate irritable bowel syndrome from IBD and for disease monitoring in IBD.15,16 Calprotectin in serum or plasma also rises in parallel with inflammatory activity in patients with IBD, and previous studies show that calprotectin in serum or plasma performs equally or better to predict inflammation compared to CRP and albumin.17–20. Here, CRP is linked to irritable bowel syndrome.