untreated mice.60,61 Furthermore, intestinal inflammation is decreased in TRPV4 knockout (KO) mice compared to wild type (WT) mice in a dextran sulfate sodium (DSS) colitis model.60 Thus, there is evidence that activation of TRPV4 has an inflammatory and pro-hypersensitivity function during colitis, and the evidence that TRPV4 antagonist had a protective effect on animal models of colitis makes it a promising therapeutic target.62 Here, TRPV4 is linked to colitis.