Recently, Swiss IBD Cohort group has shown that 2 SNPs rs1042713 (located on the ADRB2 gene) and rs4663866 (close to the HES6 gene), which are significantly associated with IBS, were also associated with abdominal pain level in patients with UC.162 This result may explain the high prevalence rate of IBS among IBD patients. The gene discussed is HES6; the disease is irritable bowel syndrome.