NPPB and hydrops fetalis: The PIONEER-HF58 (Comparison of Sacubitril-Valsartan vs Enalapril on Effect of N-Terminal Pro–Brain Natriuretic Peptide [NT-proBNP] in Patients Stabilized From an Acute HF Episode) trial further validated the benefits and safety of initiating sacubitril-valsartan in patients hospitalized for acute decompensated HF.