NPPB and hydrops fetalis: PARAGLIDE-HF (Changes in NT-proBNP and Outcomes, Safety, and Tolerability in HFpEF Patients With Acute Decompensated Heart Failure Who Have Been Stabilized During Hospitalization and Initiated In-Hospital or Within 30 Days Postdischarge; NCT03988634) is an ongoing study that will address the effect of sacubitril-valsartan compared with valsartan on time-averaged proportional change in NT-proBNP over 8 weeks among patients with HFpEF.