MME and angioedema: Neprilysin also displays enzyme promiscuity by breaking down angiotensin II and, by this mechanism, can elevate blood pressure (BP).18, 19, 20 In addition, neprilysin degrades bradykinin, which is a potent vasodilator, through the stimulation of endothelial nitric oxide production, is implicated in vasogenic edema, and can cause angioedema in excess.