CNR2 and Cowden disease: Under physiological conditions, CB2 is expressed on gastrointestinal enteric nerves, select immune cells, and on healthy colonic epithelium.10–12 CB2 expression is increased in the ulcerative margin in CD,10 and CB2 has been shown to be upregulated in the gastrointestinal tract during intestinal inflammation and to modulate visceral sensitivity in animal models.7