No significant changes in CRP or fecal calprotectin were observed with olorinab at the doses used, consistent with previous trials of cannabis or cannabidiol-rich botanical extract for ulcerative colitis that did not find a statistically significant effect on CRP, fecal calprotectin, or other disease-specific markers.29,30 This suggests that any effects on pain reduction may be independent of changes in intestinal inflammation. This evidence concerns the gene CRP and ulcerative colitis.