Patients treated with corticosteroids or anti-tumor necrosis factor alpha (anti-TNF) agents combined with immunomodulators and those on thiopurines have increased risks of severe infection.6,7 However, as all individuals in the SECURE-IBD registry have a diagnosis of COVID-19, the incidence of and risk factors for COVID-19 infection cannot be determined. The gene discussed is TNF; the disease is infection.