KL and chronic kidney disease: Yanucil et al. (2022) All These studies have led to the development of recombinant klotho and klotho derived peptides as therapeutic approaches to progression of CKD and associated cardiomyopathy (Zhou et al., 2015; Hu et al., 2017; Yuan et al., 2022). The Alpha Young LLC is a biotech start up developing a klotho mimetic as a CKD therapeutic agent. However, as Isakova et al. point out, pharmacological properties of the agents, including bioactivity and stability, need to be improved, and the mechanism of action still needs further elucidation (Isakova et al., 2022).