GSDMD and metabolic dysfunction-associated steatotic liver disease: Taken together, our results have demonstrated that 1) caspase-11 deficiency significantly reprograms liver transcriptomes in NCD and HFD livers; 2) caspase-11 deficiency attenuates hepatic macrophage pyroptosis in HFD-induced NAFLD; 3) caspase-11 cleaves GSDMD-NT in NCD livers more than that in HFD-induced NAFLD; and 4) BM-derived macrophages play more significant roles than liver resident macrophages in developing and facilitating pyroptosis.