In terms of prognostic indices, a new-generation genomic-augmented multivariate prognostic model was recently developed via the identification of 13 mutated genes which offered significant prognostic significance in terms of reduced OS and PFS in a cohort of 210 NKTCL tumors, of which including BCOR, KRAS, JAK3, DCC, FAS, NOTCH1, BIRC3, etc. and implicating 39% of the total NKTCL samples used in generation of the model (178). The gene discussed is NOTCH1; the disease is extranodal nasal NK/T cell lymphoma.