This poor prognostic significance of DNMT3A-mutant PTCL-TBX21 patients was further observed to negate the survival benefits of the PTCL-TBX21 subtype over that of the PTCL-GATA3 subgroup, resulting in similar survival curves observed between these two subgroups. The gene discussed is DNMT3A; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.