DNMT3A and mature T-cell and NK-cell non-Hodgkin lymphoma: DNMT3A is a gene that has been documented as a progenitor of PTCL oncogenesis, whereby its involvement in the PTCL-NOS subtype is characterized by mutations within its functional domains, featuring mutations skewed towards its MTase domain and a R882H/C hotspot mutation identified within roughly 30% of the PTCL-NOS cohort (43).