Modern technological options such as the utility of gene expression signatures via transcriptomic analysis have also been studied as novel means of increasing the accuracy of diagnosing each subtype of PTCL, including further substratification of PTCL-NOS into its GATA3- or TBX21-expressing subgroups (36). This evidence concerns the gene TBX21 and mature T-cell and NK-cell non-Hodgkin lymphoma.