Thus, we obtained the co-expressed genes of epilepsy and stress cardiomyopathy and the cellular subgroups they belong to in brain tissue, including the co-expressed up-regulated genes (SPOCK2 in the T_cells subgroup, CTSZ in the Microglia subgroup, HLA-DMB in the Microglia subgroup, ALDOA was expressed in NVUs and Macrophage and Astrocyte subgroups, SFRP1 in the Oligodendrocytes subgroup, ERBB3 in the Oligodendrocytes subgroup) and the co-expressed down-regulated genes (PRKCA in the Macrophages subgroup, C3 in the Microglia subgroup, GSTM3 in the Astrocyte subgroup). The gene discussed is CTSZ; the disease is Tako-tsubo cardiomyopathy.