Interestingly, C3 activates the JAK2/STAT3 pathway and is associated with the progression of gastric cancer (67), these two patterns of regulation of different pathways of the same gene in different tissues give us a hint that reduced C3 gene expression in Epilepsy and stress cardiomyopathy may have an important role. Here, C3 is linked to Tako-tsubo cardiomyopathy.