Even though most of the differentially expressed plasma factors were gradually increased or decreased depending on disease severity, it is noteworthy that several factors, including IL12p40, GZMB, IFNG, MMP12, and IL1B, were significantly upregulated in the M5 group compared with the NC, M4, or severe COVID-19 groups (Figure 1C). The gene discussed is IL1B; the disease is COVID-19.