Additionally, several factors, such as ENPP2, C5, FASLG, VWF, IFNA1, and CSF1, newly appeared as robust positive correlators strongly associated with more diverse plasma factors in the severe group than in the moderate group (Figure 4C), also indicating their enhanced impact on other plasma factors during severe pneumonic progression in COVID-19 patients. This evidence concerns the gene IFNA1 and COVID-19.