Furthermore, through the NLRP3/caspase-1/IL-1β pathway, IL-22 can reverse the overexpression of fibronectin, collagen IV, and extracellular matrix in mouse renal glomerular mesangial cells, thereby ameliorating renal fibrosis and proteinuria excretion in DN (150, 180). This evidence concerns the gene NLRP3 and renal fibrosis.