Based on the cancer immunity cycle, CD44 was positively associated with the release of cell antigens, priming and activation, recruiting of CD4 T cell, CD8 T cell, Th1 cell, Th2 cell, Th17 cell, Th22 cell, Treg cell, B cell, eosinophil, neutrophil, dendritic cell, macrophage, NK cell, and the infiltration of multiple immune cells (Figure 2B). This evidence concerns the gene CD4 and cancer.