IGHD and Hodgkins lymphoma: Being aware of this peculiar IgD expression pattern in naïve B cells, we detected a heterozygous IGHD nonsense variant (c.41_42insG; p.C15VfsX21) in exon 1 in a 22-year-old patient suffering from Hodgkin’s lymphoma during immunologic follow-up three years after completion of chemotherapy (Figures 1A–C).