In addition to GIST, increased expression of DOG1 has been reported in esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), diffuse gastric adenocarcinoma (DGAC), pancreatic adenocarcinoma (PAC), colorectal cancers (CRC) and head and neck squamous cell carcinomas (HNSCC) in recent years (12–14). The gene discussed is ANO1; the disease is colorectal carcinoma.