In the European Society of Human Reproduction and Embryology’s Guideline for RPL (12), it is recommended to screen RPL patients for LA, anti-TPO antibodies, ANAs, and APL antibodies – and among APL antibodies especially aCL antibodies since plenty of studies have documented the association between aCL antibodies and RPL whereas only few studies have documented the association between β2GPI antibodies and RPL (4). The gene discussed is FASLG; the disease is acute promyelocytic leukemia.