PLAU and carcinoma: In lung fibroblasts as well as in epithelial, carcinoma, and mesothelial cells, the expression regulation of uPA and uPAR has been shown to occur at a posttranscriptional level, which was mediated by the interaction of a 30-kD RBP to the uPA mRNA 3′UTR (86) and a 50-kD RBP to the coding region of uPAR mRNA (87–89), which resulted in destabilization of the binding of uPA/uPAR mRNA.