We generated DSS-induced or AOM/DSS-induced mice to establish experimental models of UC and CAC and found that miR-222-3p induced intestinal oxidative stress and inflammation, possibly by inhibiting the BRG1/Nrf2/HO-1 pathway in IECs, damaged the integrity of the intestinal barrier and induced colon tumorigenesis (Figure 1). The gene discussed is NFE2L2; the disease is infectious otitis media.