SAMHD1 and viral infectious disease: Interestingly, apart from lymphocyte migration and LPS signaling, several genes related to type I interferon signaling and responses to viral infection were upregulated after GF culture with DAC (APOBEC3C, IFITM1, RSAD2, IFI27, OAS2, MX1, IFI6, ISG15, SAMHD1) (Figure 5C).