IFNG and paracoccidioidomycosis: In humans and murine models of PCM, disease resistance has been associated with the secretion of interferon gamma (IFN-γ) and other antigens specific to Paracoccidioides spp T helper 1 (Th1)-secreted cytokines, whereas impaired Th1 and the prevalent secretion of Th2 cytokines have been correlated with systemic and progressive disease (11–14).