PMN-MDSCs are defined as CD11b+Ly6G+Ly6Clow, whereas M-MDSCs as CD11b+Ly6G−Ly6Chi, both of which are implicated in various aspects of immune regulation in diseases that involve chronic inflammation, such as neoplasias, infections, autoimmune diseases, and other pathologies (30). This evidence concerns the gene ITGAM and autoimmune disease.