HLA-DRA and neoplasm: in a study evaluating immune cells infiltrating the tumor microenvironment of MM and their relationship with survival, demonstrated that M2 macrophages, mediators of tissue remodelling (CD163+ pSTAT1− HLA-DRA1−), are associated with low OS whereas proinflammatory M1 macrophages (CD68+ pSTAT1+ HLA-DRA1+) have a positive correlation with survival (55).