As expected, TIO3, a specific TGF-β2 inhibitory oligodeoxynucleotide designed in our lab (12), significantly suppressed TGF-β2 mRNA and surface-bound TGF-β2 (sTGF-β2) expression in both GL261 (murine) and U251 (human) glioma cell lines (p<0.05) (Figures 1A, B, E-F). Here, TGFB2 is linked to central nervous system cancer.