In the patients of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV), the serum DNase1 activity and the ability to degrade NETs are significantly lower compared to healthy individuals, and excessive NETosis can lead to complement generation and endothelial damage (65, 66). This evidence concerns the gene DNASE1 and anti-neutrophil cytoplasmic antibody-associated vasculitis.