The crucial role of STAT3 in cytokine-mediated antibody secretion is also underlined by the fact that naïve B cells from AD-HIES patients with mutations in STAT3 cannot differentiate into antibody-secreting cells upon IL-21-/IL-10 stimulation and patients display absence of antibody-secreting long-lived plasma cells (35). The gene discussed is IL21; the disease is Alzheimer disease.