The pathogenesis of CPP has recently been linked to three genes: KISS1 (Silveira et al., 2010) encoding kisspeptin, its KISS1R receptor (Teles et al., 2008), and MKRN3, a gene deemed to act as a hypothalamic repressor on the gonadal axis (Farello et al., 2019). Here, KISS1 is linked to central precocious puberty.