GSK3β also plays a role in major depression; it is a target of mood stabilizers and antidepressants (Li and Jope, 2010), and selective GSK3β inhibitors are shown to exert antidepressant action in rodents (Gould et al., 1999; Kaidanovich-Beilin et al., 2004). This evidence concerns the gene GSK3B and major depressive disorder.