In neurological diseases, including neurodegenerative disease, acute neural injury, and dementia‐related disorders, NSC‐EVs and their pivotal cargoes (e.g., BDNF and miRNAs) effectively attenuate oxidative stress, inhibit neuroinflammation, suppress neuronal apoptosis, promote neurogenesis to replace the aging and apoptotic neurons, and restore synaptic structure and functions, leading to a significant delay in disease progression. The gene discussed is BDNF; the disease is neurodegenerative disease.