Interaction between Mediterranean diet with TCF7L2 SNP rs7903146 on obesity-related traits was also observed in a cross-section study of 1,120 Puerto Ricans of the BPRHS (150), where carriers of the “T” allele had lower WC (99.2 ± 0.9 vs. 102.2 ± 0.9 cm; Pinteraction = 0.026) and weight (77.3 ± 1.0 vs. 80.9 ± 1.0 kg; Pinteraction = 0.024) with a high Mediterranean diet score than individuals with “CC” genotype. The gene discussed is TCF7L2; the disease is obesity disorder.