GFOD2 and familial hypercholesterolemia: Similarly, in a prospective cohort study involving a dietary intervention in 41 participants with hypercholesterolemia (106), interactions were observed between consumption of a diet low in SFA (<6% TEI/day) in addition to another diet containing 15 g of soluble fiber and 25 g of soy protein for 2 months and Glucose-Fructose Oxidoreductase Domain Containing 2 (GFOD2) SNP rs12449157 on TC (Pinteraction = 0.006) and LDL (Pinteraction = 0.025).