ACE and Hypertension: In line with these findings, a case-control study of 234 elderly people (82) reported an interaction between sodium intake and angiotensin-converting enzyme (ACE) SNP rs4646994 on the risk of hypertension, where carriers of the “I/I” genotype with a high sodium intake (>2 g/day) had an increased risk of hypertension (Pinteraction = 0.007).