ATGL-mediated lipolysis has been implicated in eicosanoid synthesis in leukocytes, neutrophils, mastocytes, endothelial and cancer cells (Dichlberger et al., 2014; Schlager et al., 2015; Riederer et al., 2017; Jovičić et al., 2021). The gene discussed is PNPLA2; the disease is cancer.