In melanoma cells, DGAT1 inhibition caused excess FA oxidation and ROS generation, accompanied by activation of nuclear factor erythroid 2-related factor 2 (NRF2) signaling, which reduces ROS-mediated cellular damage through upregulation of superoxide dismutase 1 (SOD1) (Wilcock et al., 2022). The gene discussed is NFE2L2; the disease is melanoma.