Intriguingly, we found an additional two genes also enriched in homozygous disruptions, but not widely characterized as tumor-suppressor genes: PSIP1 (five observations; q = 0.006), which has previously also shown to be significantly enriched in truncating point mutations,30 and USP43 (six observations; q = 0.01), a recently proposed tumor suppressor.31 Here, PSIP1 is linked to neoplasm.