KHK4083 is a fully human, nonfucosylated IgG1 monoclonal antibody directed against OX40, that demonstrates antagonistic activity to OX40 ligand in vitro and efficacy in animal models of graft-versus-host disease and delayed-type hypersensitivity (unpublished data on file, Kyowa Kirin Pharmaceutical Development, Inc.). The gene discussed is TNFRSF4; the disease is graft versus host disease.