Treatment-emergent SAEs occurred in 8 patients receiving KHK4083: UC (n = 2), and UC+pneumonia+blood albumin decreased, abscess drainage, myocardial infarction (MI), anemia, post-procedural infection (eye infection following elective bilateral laser vision correction), and Clostridium difficile infection (each n = 1). The gene discussed is ALB; the disease is pneumonia.