In addition HMGB1 was correlated with disease activitity in pediatric and adult patients with IBS and Fecal Immunochemical Test has shown to be predictive of relapse in patients with UC.49, 50 Further the generalizability of our results is restricted to testing FC and FL concentrations using the specific laboratory testing kits described in the present study. Here, HMGB1 is linked to irritable bowel syndrome.