Insulin resistance is associated with reduced cortical insulin receptor activation, impaired clearance of amyloid-β (Aβ) oligomers, increased cerebral abnormal neurotic plaque burden, and the cerebral microvascular dysfunction which is associated with memory loss or decline of cognition (Umegaki et al., 2017; van Sloten et al., 2020). The gene discussed is INSR; the disease is Insulin resistance.