ACOD1 and infection: Notably, the expression of Irg1, a key enzyme for activation of the itaconate biosynthesis pathway linked to inflammatory macrophage phenotype (27, 28) and Mtb killing (28, 29), was markedly reduced in AM in comparison to either M1 (logFC=5.5, FDR=5.1x10-12) or M2 (logFC=3.2, FDR=1.0x10-6) BMDMs after H37Rv infection (Supplementary Figure S2A).