A paper showed that miR-223-3p was remarkably decreased in syphilis patients compared with control groups, the levels of NLRP3 and caspase1 were increased in syphilis patients, and miR-223-3p inhibited T pallidum-induced caspase1 activation, IL1β production, and Lactate dehydrogenase (LDH) release in HUVECs, the mechanism is miR-223-3p targets NLRP3 directly (114). Here, IL1B is linked to syphilis.