In this study, the protein levels of vascular cell adhesion molecule 1 (VCAM1) and intercellular adhesion molecule 1 (ICAM1) in the lung tissue of DEFA1/DEFA3-HCN mice were significantly higher than those of DEFA1/DEFA3-LCN mice and WT mice 24 hours after the onset of disease septicemia. The gene discussed is DEFA3; the disease is Sepsis.