In HFD-fed ApoE−/− mice, OxLDL stimulates pyroptotic cell death factors, including activation of MEG3 and inhibition of miR-223, resulting in NLRP3-ASC-procaspase1-assemble and activated caspase1, furthermore melatonin protected pyroptotic endothelium in ECs and improved atherosclerosis in mice models (64). The gene discussed is APOE; the disease is atherosclerosis.