MT/Alb was found to be significantly higher in ACLF vs CLD (p-value ≤0.01, Figure 4D), in ACLF-AKI vs ACLF no-AKI; (p-value ≤ 0.0001; Figure 4E) as well as in ACLF progression to AKI vs no progression to AKI, p-value≤ 0.0001; Figure 4F). The gene discussed is ALB; the disease is congenital secretory chloride diarrhea 1.