The panel consist of several proteins that shows an increased expression in amelanotic melanoma cells compared to pigmented cells, of which the most important ones seem to be represented by AHNAK, PLEC, FN1, ANXA1, ASPH, MYOF, THBS1, EPHA2, ITGA6, ITGA5, FSCN1, TGM2, ACTN4 and CAPN2. This evidence concerns the gene ITGA5 and melanoma.