EPHA2 and melanoma: In addition, ephrin type-A receptor 2 (EPHA2), fascin actin-bundling protein 1 (FSCN1), laminin subunit beta 1 (LAMB1), P antigen family member 5 (PAGE5), transglutaminase 2 (TGM2) and thrombospondin (THBS1) displayed a cell type specific pattern that underlines melanoma heterogeneity, being up-regulated in A375 cells (Figure 2I).