We have compared the quantitative proteomes of melanoma patients with high and low expression of the melanogenic proteins TYR, TYRP1, PMEL, MITF, CDK2, and found that most of the predicted markers, including AHNAK, PLEC, ANXA1, integrins, MYOF identified patients with a protein pattern that might define amelanotic melanoma. The gene discussed is TYR; the disease is melanoma.