For this analysis, we considered two main subtypes, the amelanotic and pigmented melanomas differing in the expression of the following genes: TYR, TYRP1, TYRP2, RAB32, RAB27A, MITF and MLANA rather than subtyping melanomas according to combined melanocytic and neural crest genes and MITF regulated genes (35, 36). The gene discussed is RAB27A; the disease is melanoma.