The analysis of a public proteomics dataset, The Cancer Cell Line Encyclopedia (CCLE) displaying data of 33 melanoma cell lines showed grouping of samples with high pigmentation proteins and low expression of 19 proteins that include CRIP2, FSCN1, PTRF, PLOD1, ACTN4, ITGA5, ITGA6, CNN3, FN1, THBS1, EPHA2, SCRN1, CAPN2, ASPH, PLEC, AHNAK, TGM2, MYOF, TNS3 and a different cluster including melanoma cell lines with low expression of melanin genes and an increased level of the above mentioned proteins (Figure 6A). This evidence concerns the gene CAPN2 and cancer.