Importantly however, multifunctional CD4+ and CD8+ T cells capable of specifically responding to viral antigens are retained in CD45RA+-depleted grafts suggesting that protective immunity could be transferred (38) and alloreactive CD8+ T-cells are significantly reduced suggesting that the use of a CD45RA+ depleted allogeneic graft could be associated with a lower risk of inducing GVHD (39). The gene discussed is CD4; the disease is graft versus host disease.