In univariate and multivariate analyses (Tables 2, 3), tumor size (adjusted HR 1.047, 95% CI 1.012–1.085), tumor number (adjusted HR 1.040, 95% CI 1.091–1.191), AFP (adjusted HR 1.271, 95% CI 1.010–1.600), total bilirubin (TBIL) (adjusted HR 1.021, 95% CI 1.005–1.037), ALB (adjusted HR 0.952, 95% CI 0.927–0.977), PVTT (adjusted HR 3.020, 95% CI 2.202–4.142), and EHS (adjusted HR 2.082, 95% CI 1.503–2.886) were independent significant predictors of OS (all p < 0.05). This evidence concerns the gene ALB and neoplasm.