The different signal pathways enriched in this case may be the mechanism of FIP1L1-RARA leading to different types of leukemia in different ways, further studies are needed to elucidate the mechanism of different phenotypes of leukemia caused by FIP1L1::RARA. Since not all patients with FIP1L1::RARA are APL, it is important to combine morphology with flow cytometry, karyotype analysis, FISH, and RT-PCR for accurate diagnosis. This evidence concerns the gene RARA and leukemia.