Here, we found that low expression of SHP-2 promoted exosome release in IL-4-induced M2 macrophages by activating the PI3K/AKT pathway, and was inhibited after adding LY294002, suggesting that low expression of SHP-2 may also promote the release of exosomes in M2 macrophages through the PI3K/AKT pathway and thus affect CRC. The gene discussed is AKT1; the disease is colorectal carcinoma.