In tumor-associated macrophages (TAMs), SHP-2 binds to the signaling protein complex of growth factor receptor-bound protein 2/GRB2 associated binding protein-2 (GRB2/GAB2), which is induced by colony stimulating factor receptor under the stimulation of CSF-1, and promotes macrophage proliferation and M2-type polarization. The gene discussed is GRB2; the disease is neoplasm.