In Transwell assay, it was observed that the invaded SW480 cells and HCCT116 cells in the PHPS1+IL-4 group were significantly higher than those in the IL-4 group, indicating that the low SHP-2 expression induced by PHPS1 enhanced the invasive ability of CRC cells (Figure 6C). The gene discussed is PTPN11; the disease is colorectal carcinoma.