Furthermore, the immunoinhibitors (CD276, CD274, CSF1R, HAVCR2, IL10, KDR, PDCD1LG2, TGFB1 and TGFBR1) were high expressed, while the immunostimulators (CD40LG, HHLA2, KLRK1, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFRSF18, and TNFSF18) were low expressed in BASP1high HNSCC patients (Figure 3D). Here, HHLA2 is linked to head and neck squamous cell carcinoma.