CCL21 and neoplasm: SLC-0111 treatment of HUH6 cells caused upregulation of 20 genes that were downregulated in HB tumor tissue (Table 2), including the tumor suppressor genes MT1G, MT1X, MT2A, OTC, PCK2, PGLYRP2, SERPINC1, and NR1I3. Three genes (FOXJ1, PRRT1, and TSSK5P) were downregulated in SLC-0111 treated HUH6 cells and upregulated in HB tumor tissue (Table 2).