KDM6B and Familial prostate cancer: In addition, several histone demethylases showed gene upregulation in prostate cancer tissues, including KDM1A (45), KDM3A and KDM4C (7), KDM4A (46), KDM4B (47), KDM5B (6), KDM5C (48), KDM6B (5, 49), KDM7A (43), and PHF8 (50), Among these upregulated genes, KDM4B expression was shown to correlate with patient overall survival outcomes, while KDM1A, KDM5C and KDM6B were shown to be associated with progression-free survival (45, 47–49).