Moreover, CDDP-induced CEBPD enforced the differentiation of fibroblasts toward myofibroblasts in the lung cancer microenvironment and activated the stromal cell-derived factor 4 (SDF4)/C-X-C motif chemokine receptor 4 (CXCR4) to trigger angiogenesis and distal metastasis (63). This evidence concerns the gene CXCR4 and lung cancer.