The overexpression of CEBPD protein further stabilized the MYC protein from proteasome-mediated degradation through transcription inhibition of FBXW7 (F-box and WD repeat domain containing 7), a tumor suppressor serving as an E3 ubiquitin ligase of SCF (SKP1-CUL1-F-box protein) (44) to promote the level of solute carrier family 2 member 1 (SLC2A1; a central rate-limiting factor to regulate glucose transport in many cancers) and hexokinase II (HK2; a key mediator of aerobic glycolysis responsible for the aggressive phenotype) (45, 46). The gene discussed is FBXW7; the disease is cancer.